Dr. J. Timothy Lightfoot, Ph.D.

FACSM, ACSM-RCEP, ACSM-CES

BIOGRAPHY

Dr. J. Timothy Lightfoot is currently the Debbie and Mike Hilliard Endowed Professor of Kinesiology and the Director of the Sydney and JL Huffines Institute for Sports Medicine and Human Performance at Texas A&M University. Dr. Lightfoot received his Bachelors's and Master's degrees from the University of Louisiana Monroe and his doctorate from the University of Tennessee. He completed a research consultantship with the United States National Aeronautics and Space Administration (NASA) at Kennedy Space Center in the Biomedical Laboratory and then a three-year National Institute of Health postdoctoral research fellowship in the Division of Physiology at Johns Hopkins University. He was an Assistant and Associate Professor at Florida Atlantic University for 6 years (two years as Department Chair), and a Professor at the University of North Carolina Charlotte for 14 years, 9 years of which he was Chair of the department.

 

Dr. Lightfoot has published over 85 scientific, peer-reviewed articles on the genetics of daily physical activity and exercise endurance, as well as the physiological response to high-G exposure and hemorrhage, and thus far has had ≈ $3 million in external funding from the National Institutes of Health and Department of Defense to conduct research on the genetics of physical activity. His lab also has a unique interest in the physiological responses of athletes in a variety of non-traditional venues such as auto racing and in musicians. His research has been featured in numerous general media outlets including the Los Angeles Times, the New York Times, Time.com, National Public Radio, the Rush Limbaugh Show, CNN, the NBC Today Show, MSNBC, Revista Epoca (a Brazilian weekly magazine), and on Australian National Radio. 

Dr. Lightfoot is a Fellow of the American College of Sports Medicine, an ACSM Certified Exercise Physiologist, an ACSM Registered Clinical Exercise Physiologist, a Past-President of the Southeast Regional Chapter of the American College of Sports Medicine, and a past member of the Board of Trustees for the American College of Sports Medicine.

Tim is a native Texan, married to a brilliant and beautiful woman (Faith), is the co-founder of the company Academic Career Development Services, used to race automobiles for fun, and has a passion for playing the bass guitar, which he does in live settings with a variety of bands.

 

 

Awards

  • AFS College-Level Teaching Award (2017)

  • AFS University Mentoring Award (2018)

  • Pease Family Scholar at Iowa State University. Pease Family Scholar at Iowa State University (this is a national research-based award). (2017)

  • National ACSM Citation Award in May 2018 

  • Awarded the Henry Montoye Research Scholar Award by the Southeast American College of Sports Medicine in 2010

  • University Graduate Student Mentor of the Year at Texas A&M in 2018.

  • Teacher of the Year in his College at:

       * Florida Atlantic University

       * University of North Carolina Charlotte

       * Texas A&M University

  • Alumnus of the year - the University of Louisiana Monroe in Kinesiology in 2010

  • Alumnus of the Year - the University of Tennessee in 2016

  • Keynote speaker at the 2013 Performing Arts Medical Association meeting

  • President’s Keynote Lecture at the 2014 national American College of Sports Medicine meeting

  • Keynote Speaker at the 2018 Southeast American College of Sports Medicine meeting

  • Pease Family Scholar Speaker at Iowa State University.

Professional service

  • Chair, American College of Sports Medicine Science Integration & Leadership Committee (2016-2019) Member

  • American College of Sports Medicine Publications Committee (2016-2019) Member

  • Former Chair, American College of Sports Medicine Task Force on Motorsports Safety (2001-current)

  • Associate Editor, Medicine and Science in Sports and Exercise (2015-2018)

  • Member and Founding Member of National Exercise Clinical Trials Network (NExTNet), (2013-current)

 

Teaching and Student Mentorship Awards

  • 2018 - Distinguished University Graduate Mentoring Award - Texas A&M Association of Former Students

  • 2017 - Fishcamp Namesake, Texas A&M University

  • 2017 - Distinguished College-Level Teaching Award - Texas A&M Association of Former Students

  • 2001 - Graduate Teacher of the Year, College of Nursing and Health Professions, University North Carolina Charlotte 

  • 1995 - Teacher of the Year, College of Education, Florida Atlantic University

Editorship

Associate Editor. Medicine and Science in Sports and Exercise (2015)

Leadership Positions

  • Chair. Distinguished Faculty in Aging Search Committee. (2011)

  • Chair. Heldenfels Lab Renovation Committee. (2011)

  • Chair. HLKN Tenure and Promotion Committee. (2014)

 

Selected Publications - Books and Monographs

Lightfoot, JT, AC Letsinger*, JZ Granados*. The Evolution of Genetic Mechanisms Controlling Physical Activity. (Chapter 7), pp. 80-93. In: The Routledge Handbook of Sport and Exercise Systems Genetics. Lightfoot, Hubal, Roth (eds), Routledge Publishing, Cambridge, UK, 2019.

Bray, M.S., J.E. Fulton, N.S. Kalupahana, J.T. Lightfoot. (2011) Genetic Epidemiology, Physical Activity, and Inactivity. In, C.

 

Bouchard and E.P. Hoffman (Eds.), Genetic and Molecular Aspects of Sports Performance: Volume XVIII of the Encyclopaedia of Sports Medicine, An IOC Medical Commission publication. Oxford, UK. Wiley-Blackwell

Kalupahana, N.S., N. Moustaid-Moussa, J.H. Kim, B.H. Voy, D. Bassett, M.S. Bray, J.T.Lightfoot. (2011) The regulation of physical activity by genetic mechanisms: Is there a drive to be active? In, C. Bouchard and E.P. Hoffman (Eds.), Genetic and Molecular Aspects of Sport Performance: Volume XVIII of the Encyclopaedia of Sports Medicine, An IOC Medical Commission publication. Oxford, UK. Wiley-Blackwell

Lightfoot, J.T. (2011) Can you be born a couch potato? The genomic regulation of physical activity. In, L.S. Pescatello and S.M. Roth (Eds.), Exercise Genomics. New York, NY: Humana Press

*Moore-Harrison, T, Lightfoot, JT "Driven to be Inactive?: The Genetics of Physical Activity" in Genetics of Adipose Tissue and Obesity (part of the series: Progress in Molecular Biology and Translational Science, formerly Progress in Nucleic Acid Research and Molecular Biology) Dr. C. Bouchard ed. Academic Press (a division of Elsevier)

Bray, M.S., Fulton, JE, *Kalupahana, NS, Lightfoot, JT. [8220]Genetic Epidemiology, Physical Activity and Inactivity[8221] Genetic and Molecular Aspects of Sports Performance, in (one volume of the Encyclopaedia of Sports Medicine sponsored by the International Olympic Committee). Drs. E. Hoffman and C. Bouchard eds. Wiley- Blackwell

*Kalupahana, NS, Moustaid-Moussa, N, Kim, JH, Voy, BH, Bassett, D, Lightfoot, JT "The Regulation of Activity By Genetic Mechanisms: Is There a Drive to Be Active?" in Genetic and Molecular Aspects of Sports Performance, (one volume of the Encyclopaedia of Sports Medicine sponsored by the International Olympic Committee). Drs. E. Hoffman and C. Bouchard eds. Wiley-Blackwell

Journal Articles

Letsinger, A.C., J. Z. Granados, S. E. Little, J. Timothy Lightfoot. Alleles associated with physical activity levels are estimated to be older than anatomically modern humans. PLoS One. 14(4): e0216155. 2019. https://doi.org/10.1371/journal.pone.0216155,

Reid, M. B., JT Lightfoot. The Physiology of Auto Racing: A Brief Review. Medicine and Science in Sports and Exercise. 51(12): 2548-2562. 2019

Lightfoot, JT, EJC De Geus, FW Booth, MS Bray, M den Hoed, J Kaprio, SA Kelly, D Pomp, MC Saul, MA Thomis, T Garland Jr, C Bouchard. Biological / Genetic Regulation of Physical Activity Level: Consensus from GenBioPAC. Medicine and Science in Sports and Exercise. 50(4), 863-873. 2018. doi:10.1249/MSS.0000000000001499

Lightfoot, JT, MM Bamman, FW Booth. Translation Goes Both Ways: The Power of Reverse Translation from Human Trials into Animal Models. Translational Journal of the American College of Sports Medicine. 2(5): 29-31, 2017.

Vellers, HL*, AC Letsinger*, NR Walker*, JZ Granados*, JT Lightfoot. High Fat High Sugar Diet Reduces Voluntary Wheel Running in Mice Independent of Sex Hormone Involvement. Frontiers in Physiology -Exercise Physiology. 8: article 628 (doi: 10.3389/fphys.2017.00628), 2017.

Lightfoot, JT. The McArdle[8217]s Mouse Model: Providing Important Insight into Skeletal Muscle Regulation. Med. Sci. Sports Exerc. (Commentary) Med. Sci. Sports Exerc. 48(8): 1447, 2016

Schmitt EE*, HL Vellers*, WW Porter, JT Lightfoot. Environmental endocrine disruptor inhibits voluntary physical activity in mice. Med. Sci. Sports Exerc. 48 (7), 1251-1258, 2016

Dawes, M*, KJ Kochan, PK Riggs, JT Lightfoot. Differential miRNA expression in inherently high- and low-active inbred mice. Physiol. Reports 3:7 e12469-82, 2015.

Ferguson, DP*, A David, JT Lightfoot. Optimizing the physical conditioning of the NASCAR Sprint Cup pit crew athlete. J. Strength and Conditioning Research. 29(3): 567-577, 2015

Ferguson, DP*, LJ Dangott, HL Vellers*, EE Schmitt*, JT Lightfoot. Differential protein expression in the nucleus accumbens of high and low active mice. Behavioral Brain Research. 291: 283-288, 2015.

Oliver, J*, K Abbas, JT Lightfoot, K Baskin*, B Collins*, D Wier, JP Bramhall, J Huang, JB Puschett. Comparison of neurocognitive testing and the measurement of marinobufagenin in mild traumatic brain injury: a preliminary report. J. Exp. Neuroscience. 9: 67-72, 2015

Vellers, HL*, C Irwin*, JT Lightfoot. Heart rate response of professional musicians when playing music. Medical Problems of Performing Artists. 30: 100-105, 2015.

Dawes, M*, T Moore-Harrison*, AT Hamilton, T Ceaser*, KJ Kochan, PK Riggs, JT Lightfoot. Differential gene expression in high and low active inbred mice. Biomedical Research International. Vol. 2014, Article ID 361048, 9 pages, 2014. doi:10.1155/2014/361048. PMID: 24551844, PMCID: 3914289

deGeus, EJC, M Bartels, J Kaprio, JT Lightfoot, M Thomis. (2014) Genetics of regular exercise and sedentary behaviors. Twin Research and Human Genetics 17(4): 262-271

Ferguson, DP*, LJ Dangott, EE Schmitt*, HL Vellers*, JT Lightfoot. (2014) Differential skeletal muscle proteome of high- and low-active mice. Journal of Applied Physiology 116: 1057-1067

Ferguson, DP*, LJ Dangott, JT Lightfoot. (2014) Lessons learned from vivo-morpholinos: How to avoid vivo-morpholino toxicity. BioTechniques.56(5): 251-256

Lightfoot, JT, J Morton. (2014) The physiology of dancing and singing at the same time. Voice and Speech Review. 8(3):280-287

 

Bamman, MM, DM Cooper, FW Booth, ER Chin, PD Neufer, S Trappe, JT Lightfoot, WE Kraus, MJ Joyner. (2013) Exercise Biology and Medicine: Innovative Research to Improve Global Health. Mayo Clinic Proc. (In Press)

Ferguson, DP*, EE Schmitt*, JT Lightfoot. (2013) Vivo-morpholinos induced transient knockdown of physical activity related proteins. PLoS ONE. 8(4): e61472

Lightfoot, JT. (2013) [48]1CWhy Control Activity? Evolutionary selection pressures affecting the development of physical activity genetic and biologic regulation. Biomed Research International

Bowen, R.S., Knab, A.M, Hamilton, A.T., McCall, J.R., Moore-Harrison, T.L., Lightfoot, J.T. (2012). Effects of supraphysiological doses of sex steroids on wheel-running activity in mice. Journal of Steroids and Hormonal Science. 3:110

Knab, A.M., Bowen, R.S., Hamilton, A.T., Lightfoot, J.T. (2012) Pharmacological manipulation of the dopaminergic system affects wheel-running activity in differentially active mice. Journal of Biological Regulators and Homeostatic Agents. 26(1): 119-129

Bowen, R.S., Ferguson, D.P., Lightfoot, J.T. (2011) Effects of aromatase inhibition on the physical activity levels of male mice. Journal of Steroids and Hormonal Science. S1:001

Bowen, RS, MJ Turner, JT Lightfoot. Sex Hormone Effects on Physical Activity Levels: Why Doesn't Jane Run as much as Dick? Sports Medicine 41 (1): 73:86, 2011

Ferguson, DP, RS Bowen, JT Lightfoot. Heart rate and core temperature responses of elite pit crews during automobile races. Journal of Strength and Conditioning Research. 2011. 25(8): 2075-2083

Leamy, LJ, D. Pomp, JT Lightfoot. Epistatic interactions of genes influence within-individual variation of physical activity traits in mice. Genetica. 2011. 139:813-821

Lightfoot, JT. Current Understanding of the Genetic Basis for Physical Activity. Journal of Nutrition. 2011. 141:526-530

Jung, AP, *TS Curtis, MJ Turner, JT Lightfoot. Physical Activity and Food Consumption in High- and Low-Active Inbred Mouse Strains. Med Sci Sports Exerc. 42(10):1826-1833 2010

Knab, AM, JT Lightfoot. Does the difference between physically active and couch potato lie in the dopamine system? International Journal of Biological Sciences. 6:133-150, 2010

Leamy, LJ, D Pomp, JT Lightfoot. A search for quantitative trait loci controlling within-individual variation of physical activity traits in mice. BMC Genetics. 11:83. 2010

Lightfoot, JT, L Leamy, D Pomp, MJ. Turner, AA. Fodor, *A Knab, *RS Bowen, *D Ferguson, *T Moore-Harrison, A Hamilton. Strain Screen and Haplotype Association Mapping of Wheel Running in Inbred Mouse Strains. J Appl Physiol. 109: 623-634

Other Publications

Vellers, HL, SR Kleeberger, JT Lightfoot. Inter-individual Variation in Adaptations to Endurance and Resistance Exercise Training: Genetic Approaches Towards Understanding a Complex Phenotype. Mammalian Genome. 29(1-2), 48-62, 2018. https://doi.org/10.1007/s00335-017-9732-5

Bamman, MM, DM Cooper, FW Booth, ER Chin, PD Neufer, S Trappe, JT Lightfoot, WE Kraus, MJ Joyner. (2014) Exercise Biology and Medicine: Innovative Research to Improve Global Health. Mayo Clinic Proc. 89(2):148-153.

 

Research Projects

Mechanisms of Maternal Programming to Offset Cardiac Impairment caused by Early Life Growth Restriction

PI. Michigan State University - NIH (Federal)
2020-04-01 — 2022-03-31 

Texas A&M Center for Environmental Health Research

Co-I. National Institutes of Health (DHHS/PHS/NIH) (Federal)
2019-04-01 — 2024-03-31 

Metabolic Phenotyping Using Kinetic Measurements in High-and Low-Active Mice

PI. American College of Sports Medicine (Private)
2018-02-01 — 2019-03-02 

The MENTORS (Model Education Networks to Optimize Rural Science) Project

PI. Texas A&M University Health Science Center - NIH (Federal)
2016-08-15 — 2021-07-31 

Physical Activity Impacts of a Planned Activity-Friendly Community: The What, Where, When and Why of Environmental Approaches to Obesity Prevention

Co-I. Texas A&M University Health Science Center - NIH (Federal)
2015-09-25 — 2020-08-31 

(STUDENT GRANT - HEATHER VELLERS) The Effect of Chronic Overfeeding on Voluntary Physical Activity

PI. American College of Sports Medicine Foundation (Private)
2015-07-01 — 2016-06-30 

PESCA: Nox2 Regulation in the Diaphragm Muscle with Duchenne Muscular Dystrophy

Co-PI (). TAMU Office of the Vice President for Research - PESCA (State)
2015-05-01 — 2016-04-30 

NIH Proposed Program Project Grant (P01)

PI. TAMU Office of the Vice President for Research (State)
2015-02-01 — 2017-01-31 

Genetic, Environmental and Behavioral Determinants of Obesity in Mexican American Children Living Along the Houston Ship Channel

PI. Texas A&M University Health Science Center (State)
2013-12-01 — 2018-11-30 

Undoing the Damage: Reprogramming the effects of early high sugar/high-fat diets through exercise

PI. DOD-Army Medical Research Acquisition Activity (Federal)
2013-09-15 — 2017-03-14

 

Peripheral Skeletal Muscle Mechanisms Regulating Voluntary Physical Activity

PI. DHHS-PHS-NIH (Federal)
2013-09-01 — 2018-08-31

 

Peripheral Skeletal Muscle Mechanisms Regulating Voluntary Physical Activity

PI. DHHS-PHS-NIH (Federal)
2012-09-01 — 2017-08-31

 

Genetic Mechanisms Regulating Physical Activity Behavior in Mice

PI. DHHS-PHS-NIH (Federal)
2012-07-01 — 2017-06-30

 

Hypothalamic Inflammation and Exercise: Transcriptional Mechanisms and Targets

PI. Virginia Polytechnic Institution and State University (State)
2012-04-01 — 2017-03-31

 

Genetic Basis for Exercise Performance: Responses to Exercise Training

Co-I (). DOD-Army-Medical Research and Development Command (Federal)
2011-12-01 — 2015-11-30

 

Biological Factors Controlling Physical Activity Behavior

PI. DHHS-PHS-NIH (Federal)
2011-07-01 — 2016-06-30

 

Hypothalamic Inflammation and Exercise: Transcriptional Mechanisms and Targets

PI. Virginia Polytechnic Institution and State University (State)
2011-07-01 — 2016-06-30

 

Genetic Factors Responsible for Maximal Exercise Endurance

PI. DHHS-PHS-NIH-NIAMSD (Federal)
2010-08-01 — 2011-07-30